If you make the seam correctly there are no cons, but I like the seam placed on one side or the other myself. As far as structural integrity, if you have proper support from beneath it makes no difference. Are you centering the seam for symmetry? If that is the case you might go for a seam on both sides instead.
As far as the glue goes, you can use epoxy or polyester resin for a seam (the poly glue may ONLY be used if there is no structural integrity involved. I define structural integrity like this: if the glue bond breaks & something can fall down that would be structural integrity. If it is supported from underneath, you can use polyester resin glue as the slab is not going to fall up.).
Make sure you use a knife grade glue, not a flowing or water viscosity glue. We actually have a DVD with a 30 minute segment on doing seams with polyester resin. You can find it here:
http://www.defusco.com/fabricating-stone-for-the-doityourselfer-glues-sealers-p-2299.htmlHere is my recommendation for epoxy:
http://www.defusco.com/rivo-knife-grade-epoxy-p-1427.htmlor
http://www.defusco.com/instant-install-minute-epoxy-32oz-knife-grade-p-2423.htmlHere is my recommendation for polyester resin
http://www.defusco.com/tenax-knife-grade-polyester-liter-p-1432.htmlHere is the color kit I recommend:
http://www.defusco.com/6pc-tenax-poly-color-kit-p-1439.htmlGiven the choice, I like the polyester resin better. It is easier to work with, sets up in just a few minutes, and if enough pressure is applied to the glue joint it will give and have to be re-glued, while if the same pressure is applied to an epoxy joint it won't give which will cause the slab to break next to the glue joint.
If you have any other questions you can call me at 800-289-6834.
Glad to be of service,
Mark